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Soon after this, in 1907, MA Lane, at the University of Chicago, observed two sets of cells stained differently in the pancreatic islets which he called 'alpha' (A) and 'beta' (B) (Lane)

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In vitro studies have shown that niacinamide significantly decreases the transfer of melanosomes to keratinocytes, interfering in the cell signaling pathway between keratinocytes and melanocytes, decreasing melanogenesis [43]

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