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Dysregulation of the immune system impairs the function and number of Treg cells, which are essential for maintaining self-tolerance, while increasing the differentiation of proinflammatory Th1 and Th17 cells [34,35,36]

It also feeds into the GABA shunt, an alternative metabolic pathway that produces Gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter

Some high risk groups for vitamin B12 deficiency include: elderly people- often stomach acid production decreases with age individuals who have had intestinal surgery such as weight loss surgery or laparoscopies individuals with GI issues including celiac disease, IBD, IBS (MOST OF YOU!!!) those following a vegetarian or vegan diet- due to the lack of animal protein eaten (one of the main sources of B12) individuals with pernicious anemia- do not make intrinsic factor Notice how a fair amount of the high risk individuals are those with some sort of intestinal issue

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(19(9)):3701-3704 doi:10.1016/j.radcr.2024.05.040