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This either suggests a genuinely pleiotropic mechanism or that some of the reported effects are artifacts of study design or publication concentration in a single research group

See the KPV Dosage Guide for protocol details

The exact human half-life has not been fully confirmed, but current estimates suggest it may remain active for only a few hours

Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms

If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency