After four weeks, 60% of the treated patients (6 out of 10) achieved complete healing, compared to just 12.5% (1 out of 8) in the placebo group
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reported a reduction in the activities of SOD, CAT, and GPX enzymes, along with decreased GSH levels and increased malondialdehyde (MDA) levels in BLM-induced pulmonary fibrotic tissues (Shariati et al., 2019)
Verhoeven NM, Roos B, Struys EA, Salomons GS, van der Knaap MS, Cornelis JC
The human MAPEG superfamily includes six members: 5lipoxygenase activating protein (FLAP), leukotriene C 4 synthase (both involved in leukotriene synthesis), MGST1, MGST2, MGST3 (GSTs as well as glutathione dependent peroxidases) and prostaglandin E synthase (PGES) (Bresell et al., 2005)