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Even more interesting is the fact that Shc and PLC were found to only interact with IRS-2 [121]

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Total distance (cm) was the total distance that the animal traveled, and the animals location was defined by the centroid model, focusing on the center of mass of the subject

This study aimed to compare the physiological roles of GIPR in the AP and hypothalamus by targeted regional KO of Gipr , using a floxed Gipr mouse model (Gipr fx/fx ) stereotactically injected with adeno-associated virus (AAV) encoding Cre-recombinase to generate mice with KO of Gipr in either the AP (Gipr AP-KO ) or hypothalamus (Gipr hypo-KO )