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As an embodiment of the present invention, the reagent used for controlling the reaction pH in step (1) is a solution composed of a base, water and an organic solvent, the base is selected from an organic base or an inorganic base, the organic base is selected from any one of triethylamine, N-diisopropylethylamine, pyridine, piperidine and aniline, the inorganic base is selected from any one of alkali metal hydroxide and alkali metal carbonate, such as any one of sodium hydroxide, potassium hydroxide, sodium hydrogen phosphate and potassium hydrogen phosphate

Regular monitoring and follow-up enable timely dose adjustments and identification of any safety concerns

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