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These effects collectively reduce lipid accumulation and tubular injury and improve survival following renal IRI (Li et al., 2023

The results from this study indicated that astrocyte-targeting strategy (AST) clearly protected neurons from MPTP neurotoxin in both the young and aged groups, while the effect of AST was less pronounced in older mice, since it could not prevent the decrease in tyrosine hydroxylase (TH) in the nigrostriatal pathway (Grimmig et al., 2018)

It has been reported that the variation in metformin response due to genetic variation is minimal and majority of the difference can be explained by environmental and lifestyle factors (Zhou et al., 2014)