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By contrast, incubation of Neuro-2a cells with SAMe enhanced PP2A methylation, led to the beneficial accumulation of dephosphorylated tau, and increased secretion of neuroprotective -secretase-cleaved APP fragments [173]

Superoxide anion (O 2 - ), hydroxyl (OH ), alkoxy radicals (RO ), peroxyl radicals (ROO ), nitric oxide radical (NO ), nitrogen dioxide (NO 2 ), and carbonate radical (CO 3 - ) are the few examples of radical ROS whereas non-radical ROS include singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and peroxynitrite (ONOO - ) species which can readily trigger free radical reactions in organisms [23, 24]

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