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STEP trials provided the basis for Wegovys obesity approval

How it works: IGF-1 LR3 is a modified version of insulin-like growth factor 1, engineered to last 20 to 30 hours in the body instead of 12 minutes

They are listed as controlled substances by the Drug Enforcement Administration (DEA) due to their potential for abuse, specifically a schedule IV listing for phentermine and a more concerning schedule II listing for Adderall

You lose the potential therapeutic benefits of glycine, specifically the muscle preservation support, sleep quality improvement, and anti-inflammatory effects, and the formulation may have slightly reduced stability compared to one with a dedicated buffering agent

Cancer Institute (2024)