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The economics differ significantly because tirzepatide is available as a commercial pharmaceutical product while retatrutide is currently a research compound

While Semaglutide focuses solely on GLP-1 receptors, Tirzepatide also activates GIP (glucose-dependent insulinotropic polypeptide) receptors

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Once-Weekly Semaglutide in Adults with Overweight or Obesity - PubMed Once-Weekly Semaglutide in Adults with Overweight or Obesity | New England Journal of Medicine Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial - PMC Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine Treatment Guidelines - Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults - NCBI Bookshelf Recommendations for adults (18 to 64 years) | Australian Government Department of Health, Disability and Ageing Weight loss medicine | healthdirect Obesity | healthdirect Australian Dietary Guidelines | NHMRC Updated contraception advice for Mounjaro (tirzepatide) | Therapeutic Goods Administration (TGA) GLP-1 receptor agonists - clinical practice recommendations | ANZCA GLP-1 RAs: warnings aligned over potential risk of suicidal thoughts or behaviours | Therapeutic Goods Administration (TGA) Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension - PMC Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial | Trials | JAMA | JAMA Network Online Weight Loss Consultations | Prescriptions sent via SMS A Simple Guide to Digital Prescriptions FAQs What is a GLP-1 plateau

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