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Xanthine oxidase and aldehyde oxidase also play a role in the metabolism of drugs and toxins (5)

Increased NFB activation in atherosclerosis susceptible areas leads to endothelial cell activation (Figure 1), as evidenced by increased expression of monocyte adherence proteins (VCAM-1, ICAM-1, and P-selectin) and proinflammatory receptors (toll-like receptor 2, TLR2) and cytokines (MCP-1 and IL-8) (19,23,24)

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Leptin resistance, common in obesity, may contribute to the motivational deficits seen in depression

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