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However, the increase in mGluRs-dependent signaling in the mouse model of FXS was not confirmed in human-based models, and clinical trials with mGluR inhibitors failed to produce a therapeutic effect in FXS patients [331]

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Unlike other growth hormone secretagogues that operate through alternative receptor systems, tesamorelin specifically targets the native GHRH receptor pathway, providing researchers with a tool for investigating endogenous growth hormone regulation mechanisms without disrupting natural pulsatile patterns

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