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Initially identified as a secreted factor induced by exercise and cold exposure, METRNL promotes energy expenditure and improves glucose tolerance through mechanisms involving immuneadipose crosstalk and beige adipocyte activation ( The physiological profile of METRNL is nevertheless highly attractive

Using the Broad Institute's Connectivity Map (CMap), which compares gene expression signatures across thousands of compounds, Pickart et al

Zuk PA, Zhu M, Mizuno H, et al