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This effect was abolished in UCP1-KO mice, confirming the role of UCP1 as the main regulator of TH effects at a central level [109,110]

It mimics the action of naturally occurring GLP-1, a hormone released by the intestines in response to food intake

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Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight

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