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Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

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Natural compounds such as sulforaphane, found in cruciferous vegetables, have gained prominence for their ability to activate the Nrf2-Keap1 pathway, promoting the transcription of genes encoding antioxidant enzymes, such as SOD and CAT, reinforcing the adaptive cellular response to oxidative stress [34, 35]

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