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A separate Canadian compound patent for semaglutide lapsed after Novo Nordisk failed to pay a routine $450 CAD maintenance fee in 2019

By contrast, participants without diabetes often required higher dosing to see the same scale of metabolic benefit

Non-selective beta-blockers can antagonise -mediated bronchodilation, reducing the effectiveness of salbutamol and potentially precipitating bronchospasm

[20] [21] Nevertheless, the rapid weight loss associated with GLP-1 therapy, particularly at higher doses used for obesity management, has prompted ongoing investigation into potential indirect effects on skeletal health, particularly in populations already at risk for osteoporosis