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Am J Physiol Regul Integr Comp Physiol (1996) 271:R16549

A randomized, double-blind, cross-over protocol was conducted, entailing the administration of NAC (2g/day) for 60 days and then placebo for another 60 days (or vice versa)

A recent meta-analysis confirmed that CFS/ME is associated with distinct gut microbial signatures, including reduced levels of butyrate-producing bacteria and increased abundance of Enterobacteriaceae (Jurek and Castro-Marrero, 2024)

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The family of small Rho-GTPases, Rho, Rac and Cdc42, are important regulators of microtubule growth and stabilization [40,41,42,43,44,45,46] and are activated downstream of integrin engagement [47,48,49]