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95% CI 0.05, 0.03), SGLT2is/metformin (WMD: 0.03

Therefore, it is possible that preservation of TCF7L2 expression could lead to reduce the atherosclerosis through the increase of GLP-1 receptor expression and decrease of inflammation process, although further evaluation would be necessary to demonstrate this point

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This mechanism reduces insulin resistance and improves glucose uptake without directly stimulating insulin secretion