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Importantly, clinical studies typically have indiscriminately tested interventions and have rarely utilised biomarkers or clinical symptoms to identify treatment responders, so the clinical indications are in some cases based on the authors opinion regarding the rationalisation of different management options

Systemic hyperinflammation, hypercytokinemia, and the development of cytokine storms may affect intestinal microbiota (Jung and Jung 2022)

Comparison of Melanotan I and II in Photoprotection Melanotan I is more studied, with a focus on medical uses and a better safety profile for certain skin disorders

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