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For those with obesity or type 2 diabetes, this number jumps dramatically to over 50% 18

All donors provided informed consent for research use of blood products, and procedures complied with institutional ethical guidelines

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Pipeline agents approaching clinical relevance include retatrutide (a triple agonist demonstrating greater than 28% average weight loss), CagriSema (semaglutide combined with cagrilintide), and eloralintide (an amylin analog for patients intolerant of GLP-1 side effects)