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One of the most serious health consequences of obesity is an increased risk of developing type 2 diabetes

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Although both TNFR1 and TNFR2 can intermediate neuroprotective effects under specific conditions, most of the evidence indicates that TNFR1 signalling is primarily associated with neurodegenerative and pro-inflammatory outcomes, but TNFR2 signalling more consistently promotes neuroprotection and tissue repair

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doi:10.1093/ajcn/50.2.301