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For the analogues containing D-Ala, on the other hand, disfavoring helicity near the N-terminus might lower the barrier for interconversion between the partially and fully engaged states, and thereby enhance the likelihood that multiple G protein activation cycles would be triggered by a single agonist-receptor association

Retrieved 14 May 2022, from A Phase II, Randomized, Open Label Pilot Study to Evaluate the Efficacy and Safety of Two Dosage Regimens of Subcutaneous Bioresorbable Afamelanotide Implants in Patients with Mild to Moderate Acne Vulgaris