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Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Schuler M, Hamilton DW, Kunzler TP, Sprecher CM, de Wild M, Brunette DM, et al

This creates a vicious cycle: viral inflammation depletes antioxidants, genetic bottlenecks prevent the synthesis of new antioxidants, and the resulting oxidative stress causes the mitochondria to shut down ATP production, leading to the debilitating fatigue that characterizes ME/CFS and Long COVID

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