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While they are not FDA-approved, they are created in response to drug shortages and can be a more accessible and affordable choice

Berberine is also known to cause GI upset, including cramping, diarrhea, and gas, especially when first starting or taking high doses

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BPD has also been related to a higher incidence of metabolic bone disease 15 years after surgery (257) and Tsiftsis et al

National Health and Medical Research Council, Australian Government Department of Health and Ageing & New Zealand Ministry of Health