When the data were adjusted for differences in age, sex, and body weight among the groups, all comparisons for exposure were within the no effect limits, and C max was similar between RI and ESRD groups, which were all 1020% lower than the normal renal function group (Table 2)
Both medications have been reported to show little or no change in pharmacokinetics and pharmacodynamics in patients with RI versus those with normal renal function, are well-tolerated, and exhibit a low risk of hypoglycemia, irrespective of renal function [24, 25, 29, 30]
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