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The practical caveat is that rigorous head-to-head solo-vs-combined trials remain rare in the peer-reviewed literature

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Search Within Type of Search Limit to a Database Search Databases Manually by Outline Summary: It is now known that some medications, when used chronically, can result in undesirable side effects that were not necessarily obvious or present within most initial clinical trials

In preclinical research, doses from 6 g/kg to 20 mg/kg caused no acute organ toxicity, and thorough mutagenicity, genotoxicity, and teratogenicity assays returned negative results