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Studies have shown that IGF-1 LR3 has a prolonged half-life, enhancing its effectiveness in promoting muscle growth, cell proliferation, and fat metabolism

However, human studies are limited and generally did not find effects on appetite, calorie intake, or weight loss

Retatrutide has also been subjected to human trials in patients with T2DM, showing significant reductions in body weight and HbA1c by the end of the 12th week compared to baseline values [106] (Figure 7)

Such oversight is standard for high-impact investigational drugs and ensured that all observed safety signals were evaluated impartially

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