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Their unique advantages include the ability to traverse complex biological barriers (e.g., intestinal mucus [17] and tumor extracellular matrix [18]) and respond to environmental stimuli (e.g., pH [19], temperature [20], and enzymes [21]) for targeted delivery [22,23,24], controlled release [25], and even on-site therapy (e.g., mechanical disruption of biofilms [26] or thermal ablation [27])

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Evidence from other studies have shown that ASOs, mRNA, CRISPR-Cas9 constructs, and small molecule drugs can be delivered using a lipid nanoparticle vectors [171,172,173,174]