Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses
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V. K. Khavinson, I. G. Popovich, N. S. Linkova, E. S. Mironova, and A. R. Ilina, Peptide Regulation of Gene Expression: A Systematic Review, MDPI AG, Nov. 2021. doi: 10.3390/molecules26227053
Metformin hydrochloride | Drugs | BNF NICE
Ask any provider what the evidence looks like for your specific goal, whether the benefit is likely modest or meaningful, and how they will measure progress
