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The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized

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congenital anemia from fetal blood loss (P61.3) D50.1 Sideropenic dysphagia Kelly-Paterson syndrome Plummer-Vinson syndrome D50.8 Other iron deficiency anemias Iron deficiency anemia due to inadequate dietary iron intake D50.9 Iron deficiency anemia, unspecified D51 Vitamin B12 deficiency anemia Excludes1: vitamin B12 deficiency (E53.8) D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency Addison anemia Biermer anemia Pernicious (congenital) anemia Congenital intrinsic factor deficiency D51.1 Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria Imerslund (-Gr?sbeck) syndrome Megaloblastic hereditary anemia D51.2 Transcobalamin II deficiency D51.3 Other dietary vitamin B12 deficiency anemia Vegan anemia D51.8 Other vitamin B12 deficiency anemias D51.9 Vitamin B12 deficiency anemia, unspecified D52 Folate deficiency anemia Excludes1: folate deficiency without anemia (E53.8) D52.0 Dietary folate deficiency anemia Nutritional megaloblastic anemia D52.1 Drug-induced folate deficiency anemia Code first (T36-T50) to identify drug D52.8 Other folate deficiency anemias D52.9 Folate deficiency anemia, unspecified Folic acid deficiency anemia NOS D53 Other nutritional anemias Includes: megaloblastic anemia unresponsive to vitamin B12 or folate therapy D53.0 Protein deficiency anemia Amino-acid deficiency anemia Orotaciduric anemia Excludes1: Lesch-Nyhan syndrome (E79.1) D53.1 Other megaloblastic anemias, not elsewhere classified Megaloblastic anemia NOS Excludes1: Di Guglielmo's disease (C94.0) D53.2 Scorbutic anemia Excludes1: scurvy (E54) D53.

*J Physiol Paris.* 95(1-6):295-301

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