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Along these lines, the SURMOUNT-3 phase III clinical trial revealed that patients with obesity or overweight who achieved 5.0% weight reduction with intensive lifestyle intervention prior to treatment with tirzepatide benefited the most from pharmacotherapy ( 5 Discussion and future directions The prevailing view that IF is cardioprotective largely stems from experimental rodent models and intervention studies ( A major goal for future research will be to identify dietary interventions that both optimally support patients with obesity during pharmacotherapy and maintain the metabolic and cardiovascular benefits achieved during treatment

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