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Glutathione Oxidation Chemistry and What It Means for Research Glutathione exists in two interconvertible forms: reduced glutathione (GSH), which contains a free sulfhydryl group (-SH) on the cysteine residue, and oxidized glutathione (GSSG), a disulfide-linked dimer

In vitro (made in the lab not on real people) and animal studies have shown that it may produce hormonal (estrogen-like) effects

In fact, research suggests that pairing the two together may be more effective at reducing blood sugar levels and body weight than metformin alone (at least in people with type 2 diabetes)