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Therefore, leucine represents the BCAA with the most compelling mechanistic and clinical evidence relevant to musclevascular interactions and healthy aging, justifying its emphasis in the present review

KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer

Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S

5-Amino-1MQ is an unapproved research chemical that inhibits the NNMT enzyme, with neither compound holding UK marketing authorisation

Although this insulin-deficient model primarily resembles type 1 diabetes mellitus (T1DM-like), it provides a robust and widely accepted platform to investigate diabetes-associated central nervous system alterations, particularly hyperglycaemia-driven neuroinflammation and cognitive impairment