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Bae KY, Kim SW, Shin HY, et al
10.3390/biom9080301 Biomolecules
doi: 10.20517/cdr.2024.127 268 WangJChenTGaoF
To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen
Although butyrate shows promise as a drug modifier, its efficacy in enhancing drug absorption beyond hepatic and intestinal tissues requires further investigation
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