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Oral administration of 10 mg/kg of EGCG from a presymptomatic stage delays the onset of the disease and prolongs useful life, in addition to increasing the number of motor neurons, decreasing the activation of the microglia, reducing the concentration of NF-kB, caspase-3 and iNOS in a transgenic mouse model of ALS (Xu et al., 2006) (Table 1)

Lebers hereditary optic neuropathy first causes central vision loss which can progress to blindness by early or middle adulthood (Puomila 2007)

Reduced glutathione is the active form that can directly participate in antioxidant and detoxification functions within the body

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