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Genetic Basis and Pathophysiology Most cases of MH are associated with mutations in the RYR1 gene , which encodes the ryanodine receptor type 1 (RyR1) calcium-release channel in skeletal muscle

By defining global and gene-specific DNA 5hmC modifications, we demonstrated that DMF induces 5hmC modifications to influence loci-specific chromatin structure through L2HGDH to reduce the levels of L2HG

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