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Indeed, despite the fact that UA reacted 16 times faster with peroxynitrite than ascorbate, the latter was necessary to protect endothelial NO synthase (eNOS) from the uncoupling caused by the products of the reaction between UA and peroxynitrite, proving that the antioxidant effect of UA is only complete when paired with another electron donor with lower reduction potential to neutralize free radical intermediates of this reaction [Citation86]