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Mice were exposed to CS for 1, 4, or 5 hours and then sacrificed immediately following the smoke exposure

The reduction of intracellular iron may disturb activity and homeostasis between osteoclasts and osteoblasts, leading to dysregulation of bone balance and ultimately bone loss

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Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors

This includes the release of pro-inflammatory cytokines like IL-6 and TNF-alpha, which can cross the blood-brain barrier and cause severe neuroinflammation