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A randomized controlled trial involving 30 individuals administered 200 mg/d l-theanine for four weeks reported improved mental health by relieving stress and improving cognitive functions [38]

Such challenges have been worked on by investigators from the Alzheimers, Parkinsons and prionopathy fields for decades, and we suggest that emerging methods for interrogating protein misfolding could be very applicable to research into the foundations of MS as well

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142,143,144,145 As key regulators of multiple DNA repair pathways, PARPs and sirtuins modulate the post-modification of repair components using NAD + as co-substrate (Fig