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We observed that AOAA treatment decreases cysteine and GSH levels while increases ROS and ferroptosis stresses in SCD erythroblasts (Supplementary Fig

Furthermore, the majority of patients also suffer from type 1 diabetes mellitus (T1D) [76]

According to our previous study, LAT1 (standing for L-type Amino acid Transporter 1) is indispensable for transport of essential amino acids, general amino acid homeostasis, and consequently, tumor growth ( system, an exchanger that imports cystine, the oxidized form of cysteine, and exports glutamate

Partial correlations were further tested to control for age, smoking status, gender and ethnicity