As expected, the chemically reactive metabolites were much more cytotoxic than their respective precursors and displayed comparable and steep dose-dependent decreases in cell viability ( Figure 2 )

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Its distinctive inactive-to-active conversion within the tumor microenvironment augments metabolic targeting and selectivity, which underscores its potential as a groundbreaking therapeutic strategy [186, 187]
There has been increased interest in the role human genetics and the gut microbiome play in chronic inflammatory conditions in the past decade