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For a deeper look at that mechanism, see how GLP-1 actually works for weight loss

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Similarly, in a rat MCAO model, repeated doses of LPS peripheral injections over 8 h increased microglia frequency, leukocyte infiltrate, and ischemic injury that was seen 3 days after MCAO (Langdon et al., 2010)

They also noted that patients who experienced moderate to severe gastrointestinal adverse events, like gastroparesis, were also more likely to discontinue GLP-1 use