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Sources Efficacy and Safety of Semaglutide 7.2 mg in Obesity: The STEP UP Trial

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[15] [27] In October 2025, the FDA further expanded the indication for semaglutide (as Rybelsus) to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes who are at high risk for these events

Tirzepatide is a dual GIP and GLP-1 agonist that generally produces greater weight loss than semaglutide alone