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Now, the extract did make them feel nauseated, bloated, and barfy, but maybe thats just more evidence it might be working through GLP-1, since those are common side effects of the GLP-1 mimicking drugs, like Ozempic

Bodor, E

2017;12:e0189310

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The mechanisms behind GLP-1-related headaches are not fully understood, but likely involve changes in blood sugar levels (especially during early treatment when insulin sensitivity improves rapidly), dehydration from reduced fluid intake or GI losses, and the central nervous system effects of GLP-1 receptor activation, since GLP-1 receptors exist in the brain