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It also has benefits for weight loss and brain health

The guidance around the management of B12 deficiency in people treated with metformin is a little unclear, owing to a lack of clinical evidence in this area

Shortage of vitamin B12 can also result in pernicious anemia, which may be due to impaired absorption of vitamin B12 caused by a lack of intrinsic factora substance necessary for the absorption of vitamin B12 in the intestines

Some early trial data for tirzepatide also suggests a more favourable lean mass preservation profile than semaglutide alone, though direct comparison data is limited

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