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Having an active metabolite is a unique feature of saxagliptin compared with other DPP-4 inhibitors

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Methods Participants Nineteen participants with type 2 diabetes, managed by a stable dose of metformin monotherapy (5002000 mg daily for at least 3 months), were recruited from the community and provided written informed consent

doi:10.2353/ajpath.2008.070429 Dinic S, Arambasic J, Mihailovic M, Uskokovic A, Grdovic N, Markovic J, Karadzic B, Poznanovic G, Vidakovic M (2013) Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of alpha-lipoic acid in diabetic liver

Research Use Only This product is intended for laboratory and scientific research purposes only