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2) Ferroptosis triggers DAMP release, inflammation, and immune activation

A randomised placebo-controlled trial (RCT) including 42 participants with schizophrenia, who were experiencing an acute phase of symptomatology, were randomly assigned to receive up to 2 g/d of NAC plus up to 6 mg/d of risperidone for 8 weeks as an adjunct intervention

In developmental models, prenatal alcohol exposure reprogrammes miRNA profiles in cortex, hippocampus and hypothalamus, contributing to altered corticosterone signalling, circadian gene expression and long-lasting cognitive impairment [11,21]

These cases showcase the innovation in nanoplatform design and anti-fibrotic mechanism exploration

While GPX4-induced inhibition of ferroptosis in T and B cells has been linked to weakened adaptive immune systems, the underlying molecular basis of GPX4 inhibition in DCs remains unknown