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Individuals should contact their GP or a relevant specialist before considering retatrutide if they have any of the following: A personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2): Rodent studies with GLP-1 receptor agonists have identified thyroid C-cell changes

Diagnosis Diagnosis is made based on clinical appearance and histopathology

Urea kinetics: comparison of oral and intravenous dose regimens