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The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation

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The most common reason people find themselves very thirsty at night is simple: when intake falls short during waking hours, sleep provides no chance to catch up, and the deficit compounds overnight

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