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As expected, CD36 silencing limited cell death and prevented lipid peroxidation, mitochondrial ROS production, and increased LIP, confirming the role of CD36 in PA-related ferroptosis (Fig

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Contrarily, GCN2 expression on CD8 + T cells promotes inflammatory responses and antitumor immunity, meaning that the presence of specific tumor-infiltrated immune cells might be critical for the outcomes related to GCN2 expression

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91 Thus, GSH can drive efflux-mediated resistance by both enabling antibiotic efflux and modulating the redox state of efflux pump regulators